Swiss Health Study – pilot phase (SHeS-pilot) Etude Suisse sur la santé – phase pilote, Schweizer Gesundheitsstudie – Pilotphase 10.16909-dataset-33 Racine, Céline Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Notepad++ Version 2.1 (16.07.2024) Depuis le 1er janvier 2019, la Policlinique médicale universitaire, l’Institut universitaire de médecine sociale et préventive, l’Institut universitaire romand de santé au travail, l’association Promotion Santé Vaud et la Fondation vaudoise pour le dépistage du cancer forment Unisanté, Centre universitaire de médecine générale et santé publique à Lausanne. www.unisante.ch Swiss Health Study – pilot phase (SHeS-pilot) Etude Suisse sur la santé – phase pilote, Schweizer Gesundheitsstudie – Pilotphase 10.16909-dataset-33 BOCHUD, Murielle ZWAHLEN, Marcel

SBP

Nicole Probst-Hensch

 BOCHUD, Murielle TRELLE, Sven © 2022, Federal Office of Public Health, Switzerland and Center for Primary Care and Public Health (Unisanté), Switzerland Swiss Federal Office of Public Health Swiss Federal Office for the Environment Swiss Federal Food Safety and Veterinary Office Datasets in version 2, 3 and 4. Modifications described in data description : https://data.unisante.ch/index.php/catalog/37/data-dictionary Cross-sectional study Multicentre Environmental exposure Nutrition Health status Exposure Attitude regarding health research Coronavirus WHO-quality of life Human biomonitoring HBM Biobank Biomarkers The pilot phase of the Swiss Health Study (SHeS-pilot) is a cross-sectional study on adults of both sexes and age 20-69. The study encompasses human biomonitoring HBM (spot urine and venous blood), health exams (e.g. blood pressure, anthropometry, accelerometry, lung function) and accompanying questionnaires on health status, exposure, attitude regarding health research, coronavirus and the WHO-quality of life questionnaire. Questionnaires were mostly answered online; HBM-samples were drawn in a study center, where also the health exams took place. Data/samples are available for four different types of populations: R - Random sample of participants from the general population of the Cantons of Vaud and Bern C - Convenience sample of vegans/vegetarians from a sub-study on selenium, in the Canton of Vaud S - Self-selected participants from all over Switzerland W - Wave 0 participants from a random sample of the general population of the Cantons of Vaud and Bern that was used before the pandemic. Reasoning for the separation of R and W: After the pandemic, due to the long break, a new random sample had to be drawn and a new questionnaire relating to the SARS-CoV-2 pandemic was included, that was not answered by Wave 0 participants that had already completed the study visit (31 participants). Some participants from Wave 0, however, came to the study visit when the study resumed and completed the SARS-Cov-2 questionnaire. The following data categories are available: 1. Accompanying data 2. Self-administered questionnaires data 3. Health examination data 4. Analytical data associated with collected HBM samples (blood, urine) They are subdivided into three main categories that are available as separate data packages: 1. Complete participation: Data/samples from participants who completed all steps of the study, including the study visit (data available: self-administered and interview questionnaire data, health exams and HBM-samples). 2. Partial participation: Data/samples from participants who completed the questionnaires but did not take part in the study visit (data available: self-administered questionnaire data) 3. Non-respondents: data from invited participants who refused to participate in the study but accepted to answer some general questions by phone instead. Most self-selected participants “S” only replied to the self-administered questionnaires, but 9 self-selected participants participated in the study visit. Switzerland Random sample, cantons of Vaud and Berne / Selenium sub-study convenience sample, canton of Vaud / Self-selected participation, Switzerland Individuals. Complete participation : - Random sample : N= 638 - Selenium sub-study convenience sample : N= 109* - Self-selected participants : N= 9 - Wave 0 : N= 48 - TOTAL : N = 789* *15 participants are both R and C. If R and C are used together, these doubles have to be removed manually based on the unique identifier “did”. Partial participation : - Random sample : N= 168 - Selenium sub-study convenience sample : N= 20 - Self-selected participants : N= 351 - Wave 0 : N= 21 - TOTAL : N = 560 General adult population (20-69) Questionnaire data, biological samples (blood, spot urine), clinical chemistry in blood/urine, health exams (see data catalogue). Questionnaires: - Before the study visit: self-administered online. Participants from the random sample could request a paper version of the questionnaires. - During study visit: two additional questionnaires in the form of an interview with the study nurse. Note that the questionnaires were available to participants in French, German and Italian. The English version was only developed for the codebooks and not available during data collection. Health data: - During study visit: (handgrip test, blood pressure, anthropometry, bioimpedance analysis, spirometry, oxidative potential in exhaled air (OPEA), accelerometry, food intake via a mobile app, blood and urine clinical parameters) Analytical data / Collection of biological samples: - Collected during study visit: in study center, single sample, non-fasting. Venous blood (venipuncture: whole blood, plasma LiHep, plasma EDTA, buffy coat, serum), spot urine. An interactive sample catalogue from the study biobank can be accessed via the SBP NeXT website. For information on where to find and how to use this sample catalogue, go to the “How to request data/samples from the Swiss Health Study Pilot phase” document under the tab “Documentation”. One time cross-sectional study. R: random sample Random sampling based on registries. Participants were invited to participate via a postal letter (and reminder letters when necessary). Unreached participants were further contacted by phone, if their number was available.* C: Selenium sub-study convenience sample For a sub-study on selenium, we recruited people following a vegan/ vegetarian diet since at least one year. Participants were recruited via ads placed in vegan/vegetarian restaurants, fruit/vegetable box delivery services and by the snowball method.* S: Self-selected sample Anyone interested in participating in the study was free to register via the study website. Self-selected participants could answer all online questionnaires, but were normally not invited to the study visit and sample collection. W: random sample - wave 0 Random sample based on registries from before the pandemic. Due to the long break, a new random sample had to be drawn for invitation waves 1-5 that form the sample R. *Participants from the random sample following a vegetarian/vegan diet were flagged and invited to participate in the selenium sub-study. For this reason, some participants are part of both R and C. Suppression of identifying variables, completion check of questionnaires data, correction of inconsistencies or data entry errors (using field validation information linked to variables). Céline Racine (Repository administrator) Natalie von Götz Swiss Health Study – pilot phase, Data and human biomonitoring samples of Swiss healthy adults from the cantons of Waadt and Berne, 2018-2021, https://www.schweizer-gesundheitsstudie.ch Samples can be requested by projects in the public domain (e.g. universities, FH, federal or cantonal entities) that have ethical approval of a Swiss Ethics Committee and serve a public interest. In case a confirmation of sample availability is needed for ethical approval, a pre-evaluation of the request is possible. Data can be requested without ethical approval but will also undergo the evaluation process. The data and/or samples will only be sent after a data transfer agreement has been signed between the Applicant and the Federal Office of Public Health (FOPH). The data requested has to match the described purpose of the study: only the data necessary for achieving the goals of the study will be delivered. The data has to be deleted after the end of the study. The respective publications and/or reports have to be sent to the FOPH point of contact (more information in the “How to request data/samples from the Swiss Health Study Pilot phase” document under the tab “Documentation”). FEES: The data packages are available at a fee of 100 CHF per request. 1.1.1_Demographics 789 7 CSV 1.1.2_Screening 789 139 CSV Version 3 For version 3, one obsolete variable has been deleted 1.2.1_A1 789 86 CSV 1.2.2_EX1 789 251 CSV 1.2.3_HM 789 855 CSV 1.2.4_QoL 789 30 CSV 1.2.5_Corona 789 91 CSV 1.2.6_A2 789 13 CSV 1.2.7_EX2 789 383 CSV 1.2.8_FFQ 109 318 CSV 1.3.1_UrinePoC 789 8 CSV Version 3 For version 3, recoding errors have been corrected 1.3.2_HG 789 9 CSV 1.3.3_BP 789 26 CSV 1.3.4_Anthropo 789 11 CSV 1.3.5_BIA 789 53 CSV 1.3.6_BloodPoC 789 18 CSV 1.3.7_Spirometry 789 17 CSV 1.3.8_OPEA CSV 1.3.9_Accelero CSV 1.3.10_MFR 789 59 CSV 1.4.1_BloodUrine_param 789 80 CSV Version 2.1 For version 2.1, one obsolete variable has been deleted 1.4.2_Metals 789 27 CSV Version 3 1.4.3_Glyphosate 789 4 CSV Version 4 For version 4, new results have been included. Distinction is made between LOQ and LOD 2.1.1_Demographics 560 7 CSV 2.2.1_A1 560 86 CSV 2.2.2_EX1 560 251 CSV 2.2.3_HM 560 855 CSV 2.2.4_QoL 560 30 CSV 2.2.5_Corona 560 91 CSV 3.2.1_NR 42 48 CSV Data ID