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    Home / Central Data Catalog / DDI-SYSTEMATIC-REVIEW-BIOMARKER-STRESS-V1
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Baseline values, between and within subject variability of non-invasive biomarkers of inflammation and oxidative stress

Switzerland, 2019 - 2020
Guseva Canu, Irina, Hopf, Nancy
Created on July 18, 2019 Last modified July 22, 2019 Page views 3869 Download 12 Documentation in PDF Metadata DDI/XML JSON
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Identification

Survey ID Number
DDI-Systematic-Review-biomarker-stress-V1
Title
Baseline values, between and within subject variability of non-invasive biomarkers of inflammation and oxidative stress
Country
Name Country code
Switzerland CHE
Study type
Systematic literature review and meta-analysis.
Abstract
In the field of engineered nanomaterials (ENMs) exposure biomonitoring, oxidative stress biomarkers measured in urine and exhaled breath condensate (EBC) appear promising to detect early effects. However, baseline values for the oxidative stress biomarkers are still not known. For human biomonitoring, different matrices can be used. Blood seems to be the ideal matrix for most chemicals but has an important disadvantage of being invasive. Our matrices permit a non-invasive biomonitoring.
We focus on four oxidative stress biomarkers: 8-OHdG, 8-isoprostane, malondialdehyde and H2O2. These biomarkers seems to be the most relevant for biomonitoring and for detecting early effects in workers handling ENMs.
A systematic literature review was performed to determine the baseline values of these biomarkers in urine and EBC in a healthy non-smoking adult (≥18 years) population. Searches were conducted for literature published since journal inception and up to April 2019 in the following bibliographic electronic databases: The Cochrane Central Register of controlled Trials, EMBASE, PubMed, and Web of Science. Two reviewers screened the titles and abstracts with disagreements resolved by consensus. The full-text review and the data extraction are ongoing.
A meta-analysis will be performed for each biomarker. As most of the selected studies include few participants and use non-standardized analytical methods, the results need to be harmonized to be able to establish baselines values and inter / intra individual variations.
We plan to carry out subgroup analysis by gender, by age and by country of origin. In addition, subgroup analyses will be done for people with respiratory diseases (COPD, asthma, lung cancer), for smokers and for workers exposed to ENMs.To our knowledge, this systematic review is the first providing baseline values for these four oxidative stress biomarkers. It is essential for enabling meaningful interpretation of the results from biomonitoring programs conducted in occupational and environmental settings.
Kind of Data
Text data / Systematic review requests

Version

Version Description
Version 1.0

Scope

Keywords
Keyword
Oxidative stress
inflammation
biomarkers
8-hydroxy-2-deoxyguanosine
8-isoprostane
malondialdehyde
urine
exhaled breath condensate

Coverage

Universe
Healthy non-smoking adults (≥18 years) of both sexes.

Producers and sponsors

Primary investigators
Name Affiliation
Guseva Canu, Irina Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland
Hopf, Nancy Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland
Producers
Name Affiliation Role
Hemmendinger, Maud Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Researcher
Graille, Mélanie Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Researcher
Wild, Pascal Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Researcher
Funding Agency/Sponsor
Name Abbreviation Role
European Union, Project NanoExplore (Grant N° LIFE17 ENV/GR/000285) Funder
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Unisanté Funder
Other Identifications/Acknowledgments
Affiliation Role
Lausanne University Hospital (CHUV)
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland Metadata XML document creator

Data Collection

Dates of Data Collection
Start End
2019-04-01 2020-07-01
Data Collection Mode
Bibliographic electronic databases: The Cochrane Central Register of controlled Trials (CENTRAL, Cochrane Library), EMBASE, PubMed, and Web of Science.

Data Processing

Data Editing
Two reviewers will independently performed in Rayyan QCRI a first screening of titles and abstracts retrieved during the searches. Abstracts that have provided insufficient information with regard to the inclusion and exclusion criteria will be retained and downloaded in the EndNote software for full-text analysis and re-assessed by two researchers independently. In case of disagreement on the inclusion/exclusion of one or more papers, the two reviewers will discuss their points of view; if no consensus is reached a third reviewer is consulted. This process allows to finalize the list of studies to be included in the review. Throughout this process, A PRISMA (Preferred Reporting Items for systematic Reviews and Meta-Analyses) flow diagram will be completed.

A data extraction form will be designed in advance according to the research objectives and contents of the articles. It will be tested by two independent researchers and validated by a statistician with strong experience in meta-analysis.
Two researchers will independently extract and check the published data.
The information extracted will be as follows: first author name, publication time, study type, analytic method, the sample time, the number of participants, the gender, the mean age, the mean BMI, their smoking status, season, occupation, pregnancy, diet, vitamin, exercise, outcomes, references, DOI.

Access policy

Contacts
Name Affiliation Email
Hemmendinger, Maud (first author) Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland maud.hemmendinger@unisante.ch
Racine, Céline - for technical issue only (Unit of Documentation and Data, DFRI, Unisanté) Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland celine.racine@chuv.ch
Access conditions
Open datasets, accessible without any restrictions
Citation requirements
Maud Hemmendinger, Mélanie Graille, Pascal Wild, Nancy Hopf, Irina Guseva Canu. Baseline values, between and within subject variability of non-invasive biomarkers of inflammation and oxidative stress: a systematic literature review and meta-analysis. Center for primary care and public health (unisanté), University of Lausanne, Switzerland. Version 1.0 of the licensed dataset (July 2019), provided by the IUMSP Research Data Repository. DOI:10.16909/DATASET/17

Disclaimer and copyrights

Disclaimer
The user of the data acknowledges that the original collector of the data, the authorized distributor of the data, and the relevant funding agency bear no responsibility for use of the data or for interpretations or inferences based upon such uses.
Copyright
(c) 2019, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland

Metadata production

DDI Document ID
DDI-Systematic-Review-biomarker-stress-V1
DDI Document version
Version 1.0 (July 2019)
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland
Route de Berne 113
1010 Lausanne
Switzerland
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